Publications:
Frerichs AB, Huang M, Ortiz SC, Hull CM. 2022. Methods for Manipulating Cryptococcus Spores. J Fungi (Basel). 2021;8(1):4. MDPI
Ortiz SC, Huang M, Hull CM. 2021. Discovery of Fungus-Specific Targets and Inhibitors Using Chemical Phenotyping of Pathogenic Spore Germination. mBio, e0167221. mBio bioRxiv
Ortiz SC, Huang M, and Hull CM. 2019. Spore germination as a target for antifungal therapeutics. Antimicrobial Agents Chemotherapy 63: e00994-19.
Walsh NM, Botts MR, McDermott AJ, Ortiz SC, Wüthrich M, Klein BS, and Hull CM. 2019. Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus. PLoS Pathogens 15(6): e1007777.
Rank LA, Lim FY, Walsh NP, Keller NP, Gellman SH, and Hull CM. 2018. Peptide-like nylon-3 polymers with activity against phylogenetically diverse, intrinsically drug resistant pathogenic fungi. mSphere 3(3): e00204-17.
Rank LA, Walsh NM, Liu R, Lim FY, Bok JW, Huang M, Keller NP, Gellman SH, and Hull CM. 2017. A cationic polymer that shows high antifungal activity against diverse human pathogens. Antimicrobial Agents and Chemotherapy 61(10).
McDermott AJ, Tumey TA, Huang M, Hull CM, and Klein BS. 2017. Inhaled Cryptococcus neoformans elicits allergic airway inflammation independent of Nuclear Factor Kappa B signaling in lung epithelial cells. Immunology.
Huang M and Hull CM. 2017. Sporulation: how to survive on planet Earth (and beyond). Current Genetics.
Walsh NM, Wuthrich M, Wang H, Klein B, and Hull CM. 2017. Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1. PloS One 12(3):e0173866.
Davis JM, Huang M, Botts MR, and Hull CM, Huttenlocher A. 2016. A Zebrafish model of cryptococcal infection reveals roles for macrophages, endothelial cells, and neutrophils in the establishment and control of sustained fungemia. Infection and Immunity 84(10):3047-62.
Barkal LJ, Walsh NM, Botts MR, Beebe DJ, and Hull CM. 2016. Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination. Integrative Biology 8(5):603-15.
Mead ME and Hull CM. 2016. Transcriptional control of sexual development in Cryptococcus neoformans. Journal of Microbiology 54(5):339-46.
Huang M, Hebert AS, Coon JJ, and Hull CM. 2015. Protein composition of infectious spores reveals novel sexual development and germination factors in Cryptococcus. PLoS Genetics 11(8):e1005490.
Mead ME, Stanton BC, Kruzel EK, and Hull CM. 2015. Targets of the Sex Inducer homeodomain proteins are required for fungal development and virulence in Cryptococcus neoformans. Molecular Microbiology 95(5):804-18.
Botts MR, Huang M, Borchardt RK, and Hull CM. 2014. Developmental cell fate and virulence are linked to trehalose homeostasis in Cryptococcus neoformans. Eukaryotic Cell 13(9):1158-68.
Shimizu K, Imanishi Y, Toh-e A, Uno J, Chibana H, Hull CM, and Kawamoto S. 2014. Functional characterization of PMT2, encoding a protein-O-mannosyltransferase, in the human pathogen Cryptococcus neoformans. Fungal Genetics and Biology 69:13-22.
Kruzel EK, Giles SS, and Hull CM. 2012. Analysis of Cryptococcus neoformans sexual development reveals rewiring of the pheromone-response network by a change in transcription factor identity. Genetics 191(2):435-49.
Bakkeren G, Kruzel EK, and Hull CM. 2012. “Sex and Virulence in Basidiomycete Pathogens.” Evolution of Virulence in Eukaryotic Microbes. 1st ed., Wiley-Blackwell & Sons, Inc.
Hull CM. 2011. Preventing phagocytosis takes more than a sweet disposition. Cell Host & Microbe 9(3):174-175.
Kruzel EK and Hull CM. 2010. Establishing an unusual cell type: how to make a dikaryon. Current Opinion in Microbiology 13(6):706-11.
Botts MR and Hull CM. 2010. Dueling in the lung: how Cryptococcus spores race the host for survival. Current Opinion in Microbiology 13(4):437-42.
Staudt MW, Kruzel EK, Shimizu K, and Hull CM. 2010. Characterizing the role of the microtubule binding protein Bim1 in Cryptococcus neoformans. Fungal Genetics and Biology 47(4):310-7.
Stanton BC, Giles SS, Staudt MW, Kruzel EK, and Hull CM. 2010. Allelic exchange of pheromones and their receptors reprograms sexual identity in Cryptococcus neoformans. PLoS Genetics 6(2):e1000860.
Dagenais TR, Giles SS, Aimanianda V, Latgé JP, Hull CM, and Keller NP. 2010. Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer. Infection and Immunity 78(2):823-9.
Giles SS, Dagenais TR, Botts MR, Keller NP, and Hull CM. 2009. Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infection and Immunity 77(8):3491-500.
Stanton BC, Giles SS, Kruzel EK, Warren CL, Ansari AZ, and Hull CM. 2009. Cognate Site Identifier analysis reveals novel binding properties of the Sex Inducer homeodomain proteins of Cryptococcus neoformans. Molecular Microbiology 72(6):1334-47.
Botts MR, Giles SS, Gates MA, Kozel TR, and Hull CM. 2009. Isolation and characterization of Cryptococcus neoformans spores reveal a critical role for capsule biosynthesis genes in spore biogenesis. Eukaryotic Cell 8(4):595-605.
Kent CR, Ortiz-Bermúdez P, Giles SS, and Hull CM. 2008. Formulation of a defined V8 medium for induction of sexual development of Cryptococcus neoformans. Applied and Environmental Microbiology 74(20):6248-53.
Dagenais TR, Chung D, Giles SS, Hull CM, Andes D, and Keller NP. 2008. Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus. Infection and Immunity 76(7):3214-20.
Ekena JL, Stanton BC, Schiebe-Owens JA, and Hull CM. 2008. Sexual development in Cryptococcus neoformans requires CLP1, a target of the homeodomain transcription factors Sxi1α and Sxi2a. Eukaryotic Cell 7(1):49-57.
Yan Z, Hull CM, Sun S, Heitman J, and Xu J. 2007. The mating type-specific homeodomain genes SXI1α and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Current Genetics.
Stanton BC and Hull CM. 2007. “Mating type locus control of cell identity.” Sex in Fungi; p.59-73.
Hull CM. 2006. Single gene control of a complex phenotype hangs in the balance. Proceedings of the National Academy of Sciences 103(34):12659-60.
Hull CM. 2006. “Establishment of cell identity in pathogenic fungi.” Molecular Principles of Fungal Pathogenesis; p.133-142.